A healing touch

Research
Emerging research suggests that mild sensory stimulation like touch can protect the brain if delivered within the first two hours following a stroke. Laura Bonnici speaks with experimental stroke specialist Prof. Mario Valentino to find out how uncovering the secrets of this ‘touch’ may have life-changing implications for stroke patients worldwide.
Prof. Mario Valentino

Stroke is universally devastating. Often hitting like a bolt from the blue, it is the world’s third leading cause of death. In Malta, over 10% of the deaths recorded in 2011 were due to stroke. But stroke inflicts suffering not only through a loved one’s passing. As the most common cause of severe disability, stroke can instantly rob a person of their independence and dignity—even their very personality. This impact, individually, socially, and globally, makes stroke research a top priority. 

Yet while scientists know the risk factors, signs, symptoms, and causes of both main types of stroke—whether ischemic, in which clots stop blood flow to the brain, or haemorrhagic, where blood leaks into the brain tissue from ruptured vessels—they have yet to find a concrete solution. 

A dedicated team at the Faculty of Medicine (University of Malta) hopes to change that. Using highly sophisticated technology and advanced microscopic laser imaging techniques, Dr Jasmine Vella and Dr Christian Zammit, led by Prof. Mario Valentino, can follow what happens in a rodent’s brain as a stroke unfolds in real-time. 

‘We use powerful lasers and very sensitive detectors coupled with special lenses, which allow us to capture the very fast events that unravel when a blood clot interrupts the blood supply in the brain,’ explains Valentino. ‘We observe what happens to the neighbouring blood vessels, nerve cells, and support cells, and the limb movements of the rodent throughout.’ Their aim is to find out how sensory stimulation might then help protect the brain. 

The idea stems from an accidental discovery in 2010 by members of the Frostig Group at the University of Irvine, USA. The scientists found that when the whiskers of a rodent were stimulated within a critical time window following a stroke, its brain protected itself by permanently bypassing the blocked major artery that commonly causes stroke in humans. The brain’s cortical area is capable of extensive blood flow reorganisation when damaged, which can be brought about by sensory stimulation.

The human brain can bypass damage. For example, blind individuals have limited use of their visual cortex, so the auditory and somatosensory cortex expands, giving them heightened sensitivity to hearing and touch. For stroke patients, this means that the brain can compensate for its loss of function by boosting undamaged regions in response to light, touch, or sound stimulation.

‘This accidental discovery could be life-changing for stroke patients. The key is to figure out the mechanism involved in how sensory stimulation affects stroke patients, and then establish the best ways to activate that mechanism. Perhaps touching a stroke victim’s hands and face could have a similar beneficial effect, and this is what this latest research study hopes to define,’ says Valentino. 

‘The team is now painstakingly correlating the data obtained during this brain imaging with the rodent’s movement and trajectory,’ he continues. ‘Using a motion-tracking device fitted under a sophisticated microscope, we can record the behaviour of the rodent during high-precision tactile stimulation, such as stroking their whiskers, and detect any gain of [brain] function through behavioural and locomotor readouts whilst ‘looking’ inside the brain in real-time.’

If they can prove that any protection is the direct cause of new blood vessels (or other cells) resulting from the electrical activity inspired by the sensory stimulation, then the next step would be to explore ways of redirecting these blood vessels to the affected brain area. 

The team’s track record is encouraging. In collaboration with scientists from the University Peninsula Schools of Medicine and Dentistry, UK, they made another recent breakthrough that was published in Nature Communications, identifying a new drug, QNZ-46, that could protect the rodent brain following a stroke.

‘That project was about neuroprotective agents – to create a drug that will substantially block or reduce the injury, and so benefit a wider selection of patients,’ elaborates Valentino. ‘The study identified the source and activity of the neurotransmitter glutamate, which is the cause of the damage produced in stroke. This led to the discovery that QNZ-46 prevents some damage and protects against the toxic effects of the glutamate. This is potentially the first ever non-toxic drug that could prevent cell death during a stroke, and the results from this research could lead to pharmaceutical trials.’

The use of two-photon laser-scanning microscopy allows the measurement of blood flow in single vessels concurrent with indicators of cellular activity deep within the rodent brain. Whisker stimulation evokes electrical activity that can be monitored by the use of genetically engineered calcium-sensitive and light-emitting neurons that sense the propagating waves of electrical activity.

While ongoing research in these projects has been supported through a €150,000 grant from The Alfred Mizzi Foundation through the RIDT, Valentino points out that globally-significant discoveries such as these are in constant need of support.

‘The funding of such projects is so important. This money is life-changing for people in such a predicament. Health research changes everything—our lifestyle, our quality of life, our longevity. And yet, government funding for research is still lacking. It’s only thanks to private companies and the RIDT, who realise the global potential of our work, that these projects can continue to try to change the lives of people all over the world,’ says Valentino.

And while Malta may be a small country with limited resources, the work conducted within its shores is reaching millions globally, proving that when it comes to knowledge, every contribution counts. We must continue striving for more to leave our best mark on the world. 

Help us fund more projects like this, as well as research in all the faculties, by donating to RIDT.

Link: researchtrustmalta.eu/support-research/?#donations

To patent or not to patent?

As universities and research institutions look to protect the knowledge they develop, András Havasi questions time frames, limited resources, and associated risks.
András Havasi

The last decade has seen the number of patent applications worldwide grow exponentially. Today’s innovation- and knowledge-driven economy certainly has a role to play in this. 

With over 21,000 European and around 8,000 US patent applications in 2018, the fields of medical technologies and pharmaceuticals—healthcare industries—are leading the pack. 

Why do we need all these patents?  

A patent grants its owner the right to exclude others from making, using, selling, and importing an invention for a limited time period of 20 years. What this means is market exclusivity should the invention be commercialised within this period. If the product sells, the owner will benefit financially. The moral of the story? A patent is but one early piece of the puzzle in a much longer, more arduous journey towards success.

Following a patent application, an invention usually needs years of development for it to reach its final product stage. And there are many ‘ifs’ and ‘buts’ along the way to launching a product in a market; only at this point can a patent finally start delivering the financial benefits of exclusivity. 

Product development is a race against time. The longer the development phase, the shorter the effective market exclusivity a product will have, leaving less time to make a return on the development and protection costs. If this remaining time is not long enough, and the overall balance stays in the negative, the invention could turn into a financial failure.

Some industries are more challenging than others. The IT sector is infamous for its blink-and-you-miss-it evolution. The average product life cycle on software has been reduced from three–five years to six–12 months. However, more traditional sectors cannot move that quickly.

The health sector is one example. Research, development, and regulatory approval takes much longer, spanning an average of 12–13 years from a drug’s inception to it being released on the market, leaving only seven to eight years for commercial exploitation.

So the real value of a patent is the effective length of market exclusivity, factored in with the size of the market potential. Can exclusivity in the market give a stronger position and increase profits to make a sufficient return on investment? All this makes patenting risky, irrespective of the technological content—it is a business decision first and foremost.

Companies see the opportunity in this investment and are happy to take the associated risks. But why does a university bother with patents at all and what are its aims in this ‘game’?

Universities are hubs of knowledge creation and today’s economy sees the value in that. As a result, research institutions intend to use and commercialise their know-how. And patenting is an essential part of that journey.

The ultimate goal and value of a patent remains the same, however, it serves a different purpose for universities. Patents enable them to legally protect their rights to inventions they helped nurture and claim financial compensation if the invention is lucrative. At the same time, patent protection allows the researchers to freely publish their results without jeopardising the commercial exploitation of the invention. It’s a win-win situation. Researchers can advance their careers, while the university can do its best to exploit the output of their work, bolster its social impact, and eventually reinvest the benefits into its core activity: research. 

At what price?

Patenting may start at a few hundred or thousand euros, but the costs can easily accumulate to tens or even hundreds of thousands over the years. However, this investment carries more risk for universities than for companies.

Risks have two main sources. Firstly, universities’ financial capabilities are usually more limited when compared to those of businesses. Secondly, universities are not the direct sellers of the invention’s eventual final product. For that, they need to find their commercial counterpart, a company that sees the invention’s value and commercial potential. 

This partner needs to be someone who is ready to invest in the product’s development. This is the technology transfer process, where the invention leaves the university and enters the industry. This is the greatest challenge for university inventions. Again, here the issue of time raises its head. The process of finding suitable commercial partners further shortens the effective period of market exclusivity.

A unique strategy is clearly needed here. Time and cost are top priorities. All potential inventions deserve a chance, but risks and potential losses need to be minimised. It is the knowledge transfer office’s duty to manage this. 

We minimise risks and losses by finding (or trying to find) the sweet spot of time frames with a commercial partner, all while balancing commercial potential and realistic expectations. The answer boils down to: do we have enough time to take this to market and can we justify the cost?

Using cost-optimised patenting strategy, we can postpone the first big jump in the costs to two and a half years. After this point, the costs start increasing significantly. The rule of thumb is that about five years into a patent’s lifetime the likelihood of licensing drops to a minimum. So on a practical level, a university invention needs to be commercialised very quickly. 

Maintaining a patent beyond these initial years can become unfeasible, because even the most excellent research doesn’t justify the high patenting costs if the product is not wanted by industry. And the same applies for all inventions. Even in the health sector, despite product development cycles being longer, if a product isn’t picked up patents can be a huge waste of money.

Patenting is a critical tool for research commercialisation. And universities should protect inventions and find the resources to file patent applications. However, the opportunities’ limited lifetime cannot be ignored. A university cannot fall into the trap of turning an interesting opportunity into a black hole of slowly expiring hopes. It must be diligent and level-headed, always keeping an ear on the ground for the golden goose that will make it all worth it. 

Science and coffee, anyone?

In an age of misinformation, having a grasp on current affairs and research is essential for us to be active, responsible citizens. Gillianne Saliba writes about the dire need for more dialogue and engagement from citizens and scientists alike.
Gilliane Saliba

For many, science is far removed. It’s just a subject they had to take at school. Or the star of crazy stories on newspapers, or videos and memes on social media. Opposing views are a dime a dozen. And sometimes it’s very hard to discern between them; what’s right? what’s wrong? ‘It’s complicated,’ they say, ‘it’s hard’, and so most people move on, letting others do all the talking. As a result, science and citizens have had a rocky relationship. But when the issues being discussed relate to health, technology, and our environment, that is, when they affect us directly, we need to be able to engage. 

Science Communication (SciComm for short) can offer a solution to this problem. 

SciComm can take many forms. Articles, films, museum exhibitions; you name it. In the wake of a scientific knowledge-gap in the community, SciComm has taken root and has been rapidly growing over the last 40 years. Researchers want to share their ideas and get citizens’ input, gauge interest, and see what others have to say. 

Enter Malta Café Scientifique. 

To create a safe space where people can chat about science, Malta Café Sci organises monthly science communication events in Valletta where researchers and professionals discuss topics of interest with attendees. Entrance is completely free and open to all, which attracts a diverse audience. 

What makes Malta Café Sci special is how it prioritises the public, putting their learning experience first. The events are tailored to them. Speakers keep their talks short and succinct, taking complex scientific concepts and breaking them down, discussing how the research can impact society. The Q&A session that follows is often far longer than the talk itself, opening up a dialogue within the audience. The elitist mantra of ‘it’s complicated’ is so far gone that talks, and the following question and answer portion of the evening, are put to bed with closing drinks where speakers and audience members can have one-on-one time, discussing the topic of the day. 

I have been volunteering as an organiser with Malta Café Scientifique for the last nine months. Through the experience, I have gained marketing and public speaking skills.

More importantly, I have had the privilege of a front row seat to pivotal moments in people’s lives—the moment when perception shifts. 

I’ve often had audience members come up to me after an event to tell me how the talk changed their ideas. How they are learning to be more receptive but also critical about what they learn and read online. Some point out how they usually steer clear of such events, with many wrongly thinking they aren’t smart enough for them, only to find that they not only understand, but can also participate.

Aside from all this, Malta Café Scientifique is also conducting its own research. Led by Café Sci’s project manager Danielle Martine Farrugia, we are evaluating and interviewing different science communicators about their practices. We’re also evaluating the initiative to understand its contribution to science communication in Malta. 

What we can already see is that Malta Café Sci is living, breathing proof of how people can come together when dialogue is open and welcoming. It is empowering local researchers to share their findings with citizens while giving community members the chance to learn and weigh in on work that may have ramifications for them. Where a learning process is no longer from expert to layman, but a continuous sharing of information in both directions.  

Note: For more about Malta Café Scientifique’s next events, or if you want to get involved, see its Facebook page or Instagram @maltacafesci. Or email us on cafesci@mcs.org.mt. 

SMARTAQUA: Acting fast on marine corrosion

Maintenance is not the sexiest aspect of business, but diligent corrosion monitoring in the oil, gas, and maritime industry could prevent massive environmental accidents. Inês Pimparel writes on behalf of AquaBioTech Group.
Inês Pimparel

The maritime industry is going through massive developments. Traditional oil and gas remain powerful, as does the shipping industry, but there is a big rise in more sustainable businesses such as offshore wind and solar energy farms. Corrosion affects them all equally.

The NACE International Institute estimates that corrosion costs the maritime industry between $50 and $80 billion every year. Clearly, maintenance is an expensive practice, which might lead to neglect, resulting in catastrophic environmental incidents. 

A low-cost, eco-friendly, and efficient solution is needed to monitor corrosion and enable earlier repair.

The industry currently monitors structures using ultrasonic or magnetic sensors. However, other solutions exist. The University of Aveiro (Portugal), the Norwegian research institute SINTEF, and the Maltese company AquaBioTech Group are working on SMARTAQUA, an innovative but simple approach that uses a special paint. 

Scanning electron microscope pictures of nanomaterials used in the project.

It uses environmentally-friendly nanomaterials to form a functional solid film over surfaces such as the support for a floating fish farm or the base of a wind turbine. Because the nanolayer goes directly onto the structure, it can combine colorimetric with magnetic analysis to detect corrosion as it happens. 

The detection method will be tailor-made to the depth at which the metallic structure is placed to assess the integrity of the structures. Colorimetric detection is a relatively simple, user friendly, and reliable manner of detecting corrosion in splash zones. But in submerged structures, where colorimetric detection is not possible, the use of magnetic measurements would reveal the state of coated substrates.

The approach is not completely novel. The aeronautical sector is already introducing it. The AquaBioTech Group is performing toxicity tests on the nanomaterials using marine organisms such as microalgae and mussels. After this, the team will test the nanolayer’s efficacy on metallic structures in their offshore testing site close to St Paul’s Islands.

If this technology is proven safe and effective it will revolutionise the field of monitoring activities. It will reduce transport needs when assembling new offshore structures, indirectly reducing fuel use and greenhouse gas emissions. The commercial and environmental benefits are massive.

The project is highly collaborative. It brings together a small business, a research institute, and a university; testament that success can be achieved through co-creation, inclusivity, and sustainability—and that small advances can lead to a sea of change. 

Note: This project was funded by the Research Council of Norway (through the programme of Petromaks II, project 284002), the Foundation of Science and Technology in Portugal, and the Malta Council for Science and Technology via the MarTERA – ERA-NET Co-fund scheme of H2020 of the European Commission.

STEM ambassadors thrashing stereotypes

Over the last four decades, STEM industries have risen to great heights. Scientific, technological, engineering, and mathematical minds have been called to rally. And the demand continues. How can you contribute?

Few would dispute that technological and scientific advancements dominate the 21st century. Adverts provide ample proof. From tablets to smartphones, to robot home appliances and driverless cars, our world is changing fast. As a result, we are now living in a global knowledge-based economy where information can be considered as the highest form of currency. This reality comes with both benefits and challenges. 

Statistics from 2013’s European Company Survey show that 39% of European Union-based firms had difficulty recruiting staff with STEM skills. Malta is no exception. Another report in 2018 showed that people with STEM careers are still in short supply locally, especially in the fields of healthcare, ICT, engineering, and research. So, while the jobs are available, there aren’t enough people taking up STEM careers, and this is holding Malta back. 

There are many reasons for this trend. For one, Malta has a low number of tertiary level graduates; the third lowest in the EU. An array of harmful stereotypes can also shoulder some blame. The ‘fact’ that people in math, science, and technology ‘don’t have a social life’ is unhelpful. The ‘nerd’ image is still prevalent, especially among the younger generations that are still in primary and secondary school. Then there is the ‘maleness’ associated with STEM jobs and industries. According to Eurostat statistics, in 2017, from 18 million scientists and engineers in the EU, 59% were men and 41% women. 

Still, this is far from the whole picture. 

Employers have reported instances where, despite having enough graduates to fill roles, applicants did not possess the right non-technical skills for the job. This was especially true for abilities such as communication, creative thinking, and conflict resolution. 

Many were unprepared to work in a team, to learn on the job, and to problem solve creatively. This is a real concern, especially for the country’s future. At the rate with which markets are evolving, a decade from now young people will be applying for jobs that do not exist today, and the country needs to prepare students for these roles. And it has to start now. 

The Malta Council for Science and Technology (MCST) is trying to do this through an Erasmus+ project called RAISE. They are launching an Ambassador Programme to empower young students to take up the STEM mantle. STEM Career Cafés are going to be popping up in schools all over Malta, alongside a Career Day at Esplora aimed to inform and inspire. This is where you come in.

They want undergraduates from the University of Malta and MCAST to work with Esplora by sharing your experiences in STEM and telling your stories to encourage those who may be considering a STEM career. STEM Ambassadors will gain important public engagement skills while making research and science careers more accessible.

STEM is crucial in our contemporary world; our economies depend on it. It has completely changed the way we live and opened up new prospects for a future we never imagined. For those who have already made up their mind to be a part of it, there is now the opportunity to empower others and guide them in finding their own path. 

Note: To become a STEM Ambassador, email programmes@esplora.org.mt or call 2360 2218.

The MCST, the University of Malta, and the Malta College of Arts, Science and Technology have embarked on a national campaign to promote STEM Engagement. Its first activity was a National STEM Engagement Conference.

Four reasons why we should not forget about Ebola

Author: Dr Raquel Medialdea-Carrera

Dr Raquel Medialdea-Carrera

When was the last time you heard about the Ebola virus? Many of you may recall Ebola dominating headlines in global news throughout 2014 and 2015 when it spread explosively across West Africa, claiming more than 11,300 lives.

For the last few years, Ebola has been my focus, passion, and dreaded nightmare rolled into one. In 2015, I joined a wonderful team of physicians, nurses, and scientists, that were leading the fight against Ebola in Sierra Leone. We worked in Ebola hospitals isolating patients and supporting survivors of the virus’ worst epidemic in history. Then, the World Health Organization (WHO) declared that the outbreak was over in 2016. News stations stopped covering our progress. Discussions about the disease dwindled. But the fight to eradicate Ebola was far from over. 

Since August 2018, an Ebola epidemic has spread across the Democratic Republic of Congo (DRC), affecting over 2,000 people and becoming the second largest epidemic ever recorded. Over the last few weeks, I have joined the WHO to support the fight against it in Africa.

The latest Ebola outbreak in Congo is affecting people who were already suffering from a major humanitarian crisis. People in the DRC are devastated by years of violence and conflict, resulting in the largest displacement emergency in Africa. Four and a half million are currently fleeing their homes. With over 100 different armed groups in the country, the challenge of ending this Ebola outbreak is on a whole new level. But still, there is hope.

Over the last few years, researchers have toiled hard and developed a powerful vaccine against the Ebola virus. This vaccine is still under evaluation, however, the preliminary results show a wonderful efficiency of over 97.5%. Even so, we have to remain aware. Ebola is a cruel, painful death sentence for most people who get infected, and leaves in its wake a trail of broken families, hundreds of orphans, and shattered hospitals. It decimates economies and destroys societies, leading to even more poverty and hardship. This is why we cannot forget about Ebola.  

Enter the swarm

Author: Jean Luc Farrugia 

Jean Luc Farrugia

Once upon a time, the term ‘robot’ conjured up images of futuristic machines from the realm of science fiction. However, we can find the roots of automation much closer to home.

Nature is the great teacher. In the early days, when Artificial Intelligence was driven by symbolic AI (whereby entities in an environment are represented by symbols which are processed by mathematical and logical rules to make decisions on what actions to take), Australian entrepreneur and roboticist Rodney Brooks looked to animals for inspiration. There, he observed highly intelligent behaviours; take lionesses’ ability to coordinate and hunt down prey, or elephants’ skill in navigating vast lands using their senses. These creatures needed no maps, no mathematical models, and yet left even the best robots in the dust. 

This gave rise to a slew of biologically-inspired approaches. Successful applications include domestic robot vacuums and space exploration rovers. 

Swarm Robotics is an approach that extends this concept by taking a cue from collaborative behaviours used by animals like ants or bees, all while harnessing the emerging IoT (Internet of Things) trend that allows technology to communicate.

Supervised by Prof. Ing. Simon G. Fabri, I designed a system that enabled a group of robots to intelligently arrange themselves into different patterns while in motion, just like a herd of elephants, a flock of birds, or even a group of dancers! 

Farrugia’s robots in action.

I built and tested my system using real robots, which had to transport a box to target destinations chosen by the user. Unlike previous work, the algorithms I developed are not restricted by formation shape. My robots can change shape on the fly, allowing them to adapt to the task at hand. The system is quite simple and easy to use.

The group consisted of three robots designed using inexpensive off-the-shelf components. Simulations confirmed that it could be used for larger groups. The robots could push, grasp, and cage objects to move them from point A to B. To cage an object the robots move around it to bind it, then move together to push it around. Caging proved to be the strongest method, delivering the object even when a robot became immobilised, though grasping delivered more accurate results.

Collective transportation can have a great impact on the world’s economy. From the construction and manufacturing industries, to container terminal operations, robots can replace humans to protect them from the dangerous scenarios many workers face on a daily basis. 

This research project was carried out as part of the M.Sc. in Engineering (Electrical) programme at the Faculty of Engineering. A paper entitled “Swarm Robotics for Object Transportation” was published at the UKACCControl 2018 conference, available on IEEE Xplore digital library.

https://www.facebook.com/ThinkUM/videos/493872941442263/

Saving the Maltese freshwater crab from extinction

Author: Clayton Sammut

Clayton Sammut

A considerable amount of endemic species inhabit the Maltese Islands. The Maltese freshwater crab (Qabru in Maltese) is one of them. In the 50s, the invertebrate was so abundant that freshwater crab soup was a common Maltese delicacy. And up until Malta adopted the Euro, it graced the Maltese five cent coin. The Maltese freshwater crab is unique to our heritage, but it is now threatened with extinction. 

Under the supervision of Dr Adriana Vella and the University of Malta’s conservation research group, I used various population and biological parameters to analyse the data and produce conservation recommendations.

To estimate the crab population size and density, I used two techniques known as the capture–recapture method and distance sampling in a number of repeated surveys in different sites throughout the dry (August to mid-September) and wet season (October to January). I then measured the crabs to determine their life stage and sex. This revealed more information about the reproductive population size and recruitment at each study site.

What we found was that there was an imbalance in the number of female to male breeding adults, which resulted in a small amount of offspring. This means the population cannot sustain itself, putting the species in grave danger.

Beyond health and numbers, we also directed attention to the crabs’ natural habitat. We wanted to find out whether hydrological and chemical parameters, such as water depth and water acidity, are also having an impact. As it happens, the freshwater crab’s population density is affected significantly by a water stream’s depth, width, velocity, and acidity (pH). We also found that specific sites and seasons also had an impact.

Direct water extraction, excessive use of fertilisers, and water stream channelisation are creating severe drought that suffocates the crabs during summer. So much so that adult male crabs were seen preying on their own juvenile crabs.

Looking at the rapid decline of watercourses around the Maltese Islands throughout the years, and the abuse that goes ignored and unchecked, the freshwater crab will not have a future unless we act immediately.

There are three things that we can do to undo some damage. We can fund research to determine if a reintroduction programme would work in sites which previously hosted the crab. We can also create new engineered habitats which can host the crab and bolster the population. Finally, the highly diverse habitats that are now hosting the crab can be turned into protected nature reserves. The nature reserves could engage citizens with Maltese organisms. If run as a social enterprise, it could generate funds to support important research. Protecting the animals that call our islands home is our duty as responsible citizens, but it goes beyond that. Protecting them means protecting our surroundings, our home, from a path that severs us from our roots. Protecting them is protecting ourselves. 

Redesigned hip joints need a simulator

People are living longer than ever. But a long life has its price. With age come more diseases and health issues, such as hip problems that can limit a person’s mobility. 

Hip replacement procedures have become common, although implants have a lifespan too. It might happen that a hip replacement you get at 60 needs to be replaced at 75. This is not the ideal scenario.

To minimise these cases, researchers are testing new materials and designs to prolong prostheses’ lifespans. These potential solutions need to be tested, but each test costs tens of thousands of euro. Enter, the University of Malta’s hip joint simulator.

Hip joint simulator in all its glory.

The hip joint simulator is a machine that replicates the joint movements and loads imposed on the human hip. To do so, the simulator uses three stainless steel frames, each of which can be controlled independently using motors. These motors act as the ‘muscles’ of the hip, programmed to replicate the walking cycle during testing.

When it comes to simulating load and forces, a mechanism can load the implants with weights of up to 300kg in a fraction of a second. This emulates what happens while walking, when the weight of the body rests on one leg due to the body’s shift in the centre of gravity. While running, inertial forces can cause the hip to sometimes take five times a person’s body weight.

Finally, to simulate the environment inside the human body, researchers use a specialised solution that mimics the bodily fluids surrounding the hip joint. They even warm the fluid to imitate body temperature. 

The hip joint simulator forms part of the MaltaHip project that intends to radically redesign hip implants to give them the longer lifespan patients want and need. Watch this space for more.  

The MALTAHIP project is funded by the Malta Council for Science and Technology through FUSION: The R&I Technology Development Programme 2016 (R&I-2015-023T).