Stereotypical depictions of researchers involve crazy hair, oversized goggles, shabby lab coats, and loads of test tubes. While the first three may be exaggerated, the sheer volume of tubes and wells needed in a lab cannot be overstated, especially when the lab is dedicated to anything biological.
One tissue sample can be used for a gamut of tests, all of them attempting to identify something different in it, be they antibodies, DNA, or RNA (biomarkers). Often, many samples are required due to all the tests needed to highlight the variations in those biomarkers. But the size of samples is now decreasing thanks to machines like the Luminex System running xMAP technology.
The Luminex System is a research/clinical diagnostics platform that allows detection of multiple analytes in a single well of a microtiter plate—100 or more reactions using a single drop of fluid.
Multiplex assays are widely used in experiments investigating the characteristics of molecules within a biological sample. This approach can be used to see whether an experimental treatment works, or what changes a DNA mutation causes in the molecules or molecular pathways within cells.
In real terms, this machine allows for analyses to be done to determine whether or not a patient has a particular disease or gene variant in their blood that would prevent a drug from being effective. It also allows them to determine the ideal dosage for those drugs. The machine can also be used to identify and characterise viral infections.
A particular research group at the University of Malta, headed by Prof. Godfrey Grech, has used Luminex xMAP technology to develop novel markers which are allowing them to classify a subset of triple-negative breast cancer
patients.
By identifying these biomarkers, it may be possible in future to detect the disease earlier and give patients better-targeted therapy.
The world is changing. Technologies are developing rapidly as research feeds the accelerating progress of civilisation. As a result, the job market is reacting and evolving. The question is: Are people adapting fast enough to keep up? Words byGiulia Buhagiar and Cassi Camilleri.
Mur studja ha tilħaq.’ (Study for a successful future.)
From an early age, most Maltese students are conditioned to think this way. You need a ‘proper education’ to land yourself a ‘good job’. But students graduate, and with freshly printed degrees in hand, they head into the job market only to be disappointed when the role they land seems unrelated to their degree. Yet vacancies are ready for the taking; there are many unfilled jobs in the STEM fields, which create 26% of all new vacancies according to recent research from the National Statistics Office.
So, if there are vacancies available, what is the problem? A skills gap.
Academic qualifications do not guarantee that graduates have the right skills for work. At a conference addressing the skills gap organised by the Malta University Holding Company (MUHC) and the Malta Business Bureau (MBB), Altaro Software co-founder and CEO David Vella confirmed this problem. In previous years, Altaro mostly employed experienced developers; however, increased demand led them to realise that there weren’t enough of these candidates out there for them.
To fill those roles, they extended the call to younger people, but Vella found that they were not fully equipped and ready to go. This was when he realised that they needed to change tactics. ‘Now we realise that we need to start hiring junior people and build up their skills.’ Investment needs to be made by both sides.’
What every relationship needs
Better communication between business and academia could improve the skills gap. However, this kind of engagement is easier to manage in some institutions and industries than others, and bringing those worlds together poses many challenges. At the same conference, MUHC CEO Joe Azzopardi noted how start-ups and small businesses often do not have the resources to organise such exchanges. The wall between them and students is a difficult one to get over. However, there is a new initiative seeking to remedy this situation.
Go&Learn is a project bridging education and industry through an online platform that effectively catalogues training seminars and company visits in a multitude of sectors, for students and educators alike. The initiative has garnered a slew of supporters. Sixty companies from all over the world are listed on the site, including some local names: Thought3D, ZAAR, and Contribute Water, to name a few. This year was Go&Learn’s third edition, and with 17 European regions from across 10 countries involved, it focused on the STEM fields. In Malta, the team behind Go&Learn, also a collaboration between MUHC and the MBB, have worked together to create two new programmes.
One was dedicated to ICT for business, leisure, and commodity. It saw students visit and learn from local companies Altaro, Scope, MightyBox, Trilith, and Flat Number. Students said that the visits helped them achieve a better understanding of the sector and its nuances. ‘For us students, the fact that we are exposed to the internal working of a business’s environment, it’s an eye-opener,’ said University of Malta (UM) student Maria Cutajar. The second was related to food, involving Elty food, Benna, Fifth Flavour, Da Vinci Pasticceria, and Contribute Water. In this case, the opportunity even attracted foreign students. Go&Learn is acting as a vital bridge between education and industry that can help to minimise the skills gap.
The skills gap exists for many reasons: prejudices towards certain industries, lack of information available on others, and much more. However, education can play an important part in fixing this problem.
Bringing STEM to life
The skills gap exists for many reasons: prejudices towards certain industries, lack of information available on others, and much more. However, education can play an important part in fixing this problem. Currently, local systems are falling short of reacting quickly and addressing new needs in industry. A lot of attention is placed on short-term goals such as exams and assignments, rather than the bigger picture and real-world tasks. This kind of attitude in science education tends to be exacerbated by the notion that its subjects are for ‘nerds’ and ‘brainiacs’. This can be a daunting prospect for young children who don’t see themselves as ‘smart enough’. It can drive lots of young talent away from STEM subjects.
We need to bring fresh talent into STEM by showing how exciting, accessible, and relevant the field actually is. The solution, UM Rector Prof. Alfred Vella says, is to start right at the beginning: ‘We need to inspire teachers.’ This includes attracting the best teachers by providing appropriate salaries. Through education, we need to change the impressions given to children about science and what it means. ‘When I was younger, they used to tell me, why do you want to do science? Wouldn’t it be better to be a doctor? Engineers were seen more as grease monkeys,’ Vella said with a smile. Science should be engaging, inspiring, and fun. For this reason, he commends ESPLORA as being ‘the single most important feature in Malta.’ Vella believes classrooms should be an extension of the ESPLORA centre in their efforts to bring science to life. In addition to teachers inspiring future generations, parents also need to see STEM jobs as a good career for their children, and businesses need to show parents that exciting careers are available by pursuing STEM subjects. Without this, early encouragement might be fruitless.
With more young people taking up STEM subjects, the potential ripple effect will be vast. These future professionals will be able to conduct more research. The enormous benefits to be reaped from having more people excited about STEM subjects means the burden does not fall solely at the feet of teachers and parents. ‘It is also the job of businesses to show the relevance and benefits of STEM,’ says the CEO of the MBB, Joe Tanti. Go&Learn is providing an arena for business to interact with students and for universities to use their influence positively.
Looking ahead
From children’s classrooms to the skills gap in our economy, everything is intertwined. We need a multi-pronged approach to tackle as many aspects as possible and implement lasting changes. For one thing, we need to take a good look at our education system and how it treats STEM subjects. We also need to bring business and education together, enabling them to communicate more effectively. With Go&Learn starting this much-needed shift, the door is open to more innovative initiatives. Who’s in?
Marine litter is a problem found across the world. As well as being directly deposited in seas and oceans, plastic, wood, rope, and other items are accumulating on land and making their way into bodies of water. On the Maltese Islands, such littering happens frequently. Last summer the Physical Oceanography Research Group (Faculty of Science, University of Malta [UM]) took a step towards tackling the issue.
Under the supervision of Prof. Alan Deidun and Adam Gauci, I sought to harness innovative techniques and create a monitoring programme that would begin to identify what kind of litter is on Malta and Gozo’s beaches.
The national Marine Strategy Framework Directive was followed to ensure good data collection and meeting of the ‘Good Environmental Status’ by 2020. The study used images captured by a drone in three coastline areas: the north east Marine Protected Area of Malta, Qawra Point, and the eastern and western points of Baħar Iċ-Ċagħaq. Flying at an altitude of 30 meters, the drone was programmed to spot specific categories of marine and coastal litter. These included plastic, wood, rope, rubber, and other miscellaneous items such as washing machines and mattresses.
Apart from characterising marine litter, the project aimed to observe whether hydrodynamical phenomena, such as wind and currents, are also influencing the accumulation of litter. However, results showed that the difference between the areas of study was not due to dynamics of coastal currents and coastal topography, but to human activities. In Baħar iċ-Ċagħaq, for example, categories such as wood and plastic were found on land at considerable distances from the shoreline, close to points easily accessible by cars.
We also used statistical analyses to confirm that parameters such as tourism, lack of public knowledge, and lack of environmental consciousness are affecting the accumulation of marine litter, laying the blame firmly on human activities.
The remedy to the situation is in Maltese citizens’ hands. Only we have the power to turn things around. It’s time to clean up our act.
This research was carried out as part of a Masters in Physical Oceanography, Faculty of Science, UM.
The Maltese Islands, despite their miniscule terrestrial extent, have always managed to punch way above their weight when it comes to aquatic matters. Hosting the International Ocean Institute, the Islands also have a pivotal role in the formulation of the Law of the Sea through the Maltese representative to the United Nations, Arvid Pardo. The ‘father of the law of the sea’, as he is affectionately known, delivered a prophetic speech to the UN General Assembly on November 1st, 1967. He described the sea as ‘the common heritage of mankind’, a phrase which still resonates to this very day, and which is enshrined within Article 136 of the United Nations Convention on the Law of the Sea.
Europe’s seas are currently being assessed more than ever for their potential, as Blue Growth (the long term strategy to support sustainable growth in the marine and maritime sectors as a whole) gains greater traction throughout the continent. We are plumbing our seas to greater depths in the search for elusive minerals, cures, genetic resources, energy sources, and a plethora of other untapped assets. In the race to unlock more of the ocean’s secrets, ocean literacy assumes a compelling role—to revise the paradigm of human impacts on our ocean so far. In fact, in the history of human exploitation of the ocean, we first exerted deleterious impacts on the ocean environment, only to become aware of those impacts and resort to ocean literacy to generate further awareness, control, and change.
The challenge now is to anticipate developments. A precautionary approach is needed to soften impacts when venturing into unchartered grounds. Some might label this utopic, I prefer to call it ‘foresight.’ For us to reach this stage, governments and institutions must invest heavily in ocean literacy to ensure more responsible use and treatment of that 70% of our planet. It is imperative for potential investors to have a grounding in ocean literacy principles, with the aim of paralleling the considerable success being had introducing ocean literacy concepts within school curricula and initiatives across Europe.
We are gearing up towards the International Decade of Ocean Science for Sustainable Development. Proposed by UNESCO last Juneat the Ocean Conference in New York, it will span from 2021 until 2030. The considerable number of abstracts submitted for the European Marine Scientists Educators Association (EMSEA) Malta conference, now approaching the 70 mark, is testimony to the profile that EMSEA has managed to achieve since its establishment a decade ago. It also confirms the status that ocean literacy now holds across the European continent and beyond. Let’s keep the momentum going!
Donation of human tissues has been at the core of medical research in Europe since religious restraints were relaxed towards the end of the Middle Ages, making this altruistic act socially and morally acceptable. Altruism is the key word—the individual donates their tissues for the greater good: for the advancement of science, the extension of boundaries of medical knowledge, and for the potential to deliver better medical care. The individual donating their tissues or blood does so with no expectation of return or personal gain, and hands over sample ownership to the scientific community in confidence that ethical use will be made of it.
Many would assume this is still the case… but is it? Genomic research has opened up new and exciting avenues for medical research that have the potential to dramatically transform the way medical practitioners strategically select treatment regimes. Personalised medicine is no longer a pipe dream, it is clearly in the cards—the pack has been dealt, and the game is well underway.
The game-changer here is the genome. The established practice of donors passively handing over their samples of blood or tissues for research is impacted by the fact that DNA is in focus here. Their DNA.
Dr Gillian M. Martin
Should this make any difference? Some argue that the fundamental process of donating for the greater good, with no consequent active involvement, is still the cornerstone of the process. There are, however, important shifts in the current social and cultural context that impact the researcher-donor dynamic. Two of these are of particular relevance here. The first is knowledge: the accessibility (via the web) of information about the research process, its impacts and applications, have led to the burgeoning new field of citizen engagement in research. Genomic research, in particular, attracts participants who are personally motivated in the process, with research into genetically linked diseases offering hope for their relatives and future generations. The second shift is that of rights over personal data. Individuals’ rights to the control of their personal data are to be entrenched in the General Data Protection Regulation in May 2018. This EU regulation will sanction a process that is already clear in practice: the trend for individuals to demand control over the ways their personal data are used and stored.
This is where the detached and passive sample ‘donor’ exits stage left, and the research participant takes the limelight. Cynics might claim that nothing much has changed. Samples are collected with consent and research continues, but there is an exciting difference in the dynamics involved. The participant now has the potential to remain engaged by using a process of web-based consent. The various versions of this eConsent or ‘dynamic consent’ that are now available offer the participant and researcher a real-time channel of communication which enables optimum use and reuse of the sample and the accompanying personal data that make it so valuable. The biomedical samples now come with persons digitally-attached: individuals who actively engage in the research process by offering flexible consent via web-based tools. When pooled and stored within biobanks, these samples offer a viable source of DNA with real potential for wide use in research.
Within this scenario, ethicality is enhanced as banked anonymised samples can be used to their full potential and shared, with consent, within the research community. In this way doing justice to the individual participant’s key motivation: to advance scientific knowledge for the benefit of future generations.
Climate change is a real threat. The scientific evidence is irrefutable. The problem is that countless talks and rallies calling for action have only pushed things forward at a snail’s pace. Prof. Simone Borg explains why.
Our globalised economy has generated wealth and prosperity for millions of people around the world. Living standards have been raised to unprecedented levels. But this comes at a cost. The environment has suffered greatly, not only in terms of constant extraction of natural resources, but also at the hands of polluting processes and end-of-pipe waste.
Recognising that economies, and indeed our planet, have finite resources, the circular economy has become a popular concept among policymakers and stakeholders in recent years. The current linear ‘take, make, use, and throw away’ model of production entails substantial value losses and negative effects along the material chain. Because of this, we should ideally be designing and manufacturing products for continuous reuse and recycling, maximising resource efficiency, and minimising leakages and waste.
The appeal of the circular economy lies in its various environmental and economic benefits. Using secondhand materials and waste within business could cut costs, while their sale adds a potential revenue stream. The circular economy also offers new and vast business opportunities in areas such as product eco-design and product/material regeneration, all of which help create high-skilled jobs and investment in new technology.
The idea of the circular economy is particularly relevant to Malta, given its geographical circumstances, high import dependency, and lack of natural resources. Embracing the principles embodied within the circular economy concept would have an immediate positive impact on the environment while benefitting Malta’s long-term economic prospects.
However, we are still at the doorstep of circularity. Malta’s natural resource productivity fell by 7.6% between 2000 and 2015, with increased domestic material consumption outpacing economic growth. Waste management in key sectors like construction remains a major issue.
To encourage the shift from concept to the creation of circular economy business models, the University of Malta is part of the R2Pi Horizon 2020 project. Among other goals, it hopes to identify both market and policy failures that hinder the uptake of such models by business entities across Europe.
Silicon is the go-to material for solar devices like photovoltaic panels despite its relatively low energy conversion rate of 15-22%. Researchers all over the world are analysing materials and creating new ones to find a better solution. A lucky handful are armed with a laser scattering tomograph (LST), the best instrument for the task.
An LST illuminates the sample material with an infrared laser beam, which scatters wherever it finds a defect. If there is a defect in a material’s structure, even one just a few nanometers wide, the very sensitive CCD camera at the other end of the machine will pick it up, allowing researchers to learn and adapt. It also boasts a robotic system that allows it to automatically load multiple samples at once.
The LST is very rare, but fortunately, one has found a home at the University of Malta’s (UM) Institute for Sustainable Energy (ISE), a brand new, state-of-the-art facility aimed towards finding efficient solutions for harnessing solar power to its fullest extent. ‘There are probably 10 to 12 of these worldwide,’ confirms Prof. Luciano Mule’ Stagno, Director of the Lab at the ISE. ‘Ours is one of the few in the world to be found in a university, almost certainly the only one in a university in Europe. Most of these machines are in industry settings,’ he says.
This enables the UM to conduct cutting-edge research in a field that is practically nascent, putting it at the forefront. With the LST, material engineers could unlock the secrets behind the perfect variation of defect-reduced silicon. This rise in efficiency could have a substantial impact on the worldwide sustainable energy market.
The Sun is the most important source of energy for life on Earth. Powerful as it is, what would happen if humankind could create a miniature sun in a lab and harness its energy? This is the mission of Dr Ing. Nicholas Sammut, Dr Ing. Andrew Sammut, and Karl Buhagiar.
Malta is not a resource rich country, but in the shift towards renewable energies, our sunshine is now coveted for more than just tanning. Hans-Joachim Sonntag talks to Prof. Luciano MulèStagno about his experience in improving solar panel materials and building a research facility from scratch. Continue reading
We need to bring fresh talent into STEM by showing how exciting, accessible, and relevant the field actually is. The solution, UM Rector Prof. 
