Saving the Maltese freshwater crab from extinction

Author: Clayton Sammut

Clayton Sammut

A considerable amount of endemic species inhabit the Maltese Islands. The Maltese freshwater crab (Qabru in Maltese) is one of them. In the 50s, the invertebrate was so abundant that freshwater crab soup was a common Maltese delicacy. And up until Malta adopted the Euro, it graced the Maltese five cent coin. The Maltese freshwater crab is unique to our heritage, but it is now threatened with extinction. 

Under the supervision of Dr Adriana Vella and the University of Malta’s conservation research group, I used various population and biological parameters to analyse the data and produce conservation recommendations.

To estimate the crab population size and density, I used two techniques known as the capture–recapture method and distance sampling in a number of repeated surveys in different sites throughout the dry (August to mid-September) and wet season (October to January). I then measured the crabs to determine their life stage and sex. This revealed more information about the reproductive population size and recruitment at each study site.

What we found was that there was an imbalance in the number of female to male breeding adults, which resulted in a small amount of offspring. This means the population cannot sustain itself, putting the species in grave danger.

Beyond health and numbers, we also directed attention to the crabs’ natural habitat. We wanted to find out whether hydrological and chemical parameters, such as water depth and water acidity, are also having an impact. As it happens, the freshwater crab’s population density is affected significantly by a water stream’s depth, width, velocity, and acidity (pH). We also found that specific sites and seasons also had an impact.

Direct water extraction, excessive use of fertilisers, and water stream channelisation are creating severe drought that suffocates the crabs during summer. So much so that adult male crabs were seen preying on their own juvenile crabs.

Looking at the rapid decline of watercourses around the Maltese Islands throughout the years, and the abuse that goes ignored and unchecked, the freshwater crab will not have a future unless we act immediately.

There are three things that we can do to undo some damage. We can fund research to determine if a reintroduction programme would work in sites which previously hosted the crab. We can also create new engineered habitats which can host the crab and bolster the population. Finally, the highly diverse habitats that are now hosting the crab can be turned into protected nature reserves. The nature reserves could engage citizens with Maltese organisms. If run as a social enterprise, it could generate funds to support important research. Protecting the animals that call our islands home is our duty as responsible citizens, but it goes beyond that. Protecting them means protecting our surroundings, our home, from a path that severs us from our roots. Protecting them is protecting ourselves. 

Voices for freedom and choice

Author: Dr Alexander Clayman

Dr Alexander Clayman

Abortion is a criminal offence in Malta. This means Maltese women who wish to end their pregnancy have severely limited choices. Those more affluent can pay to terminate their pregnancy abroad. Those who do not have the money can either continue the pregnancy against their will or terminate locally under unsafe conditions, risking both their health and freedom. 

Any woman who undertakes an abortion potentially faces three years in jail. Anybody who assists, such as a doctor, could also be sentenced to four years behind bars. This flies in the face of best medical practice which states that safe abortion services should be accessible to women who need them. 

A few weeks ago a group of doctors, including myself, came together to set up Doctors for Choice Malta in order to advocate for sexual and reproductive health. This includes comprehensive sex education (NOT abstinence-only education) and access to free contraception (condoms, pills, and intrauterine devices). Increased use of contraception alone results in fewer unwanted pregnancies and subsequent abortions. Putting contraceptives in the hands of comprehensively sex-educated individuals can do even more. This said, abortion still needs to be available to those people who need it. 

As a doctor, I feel I have a duty to use my knowledge and skills to better my community’s health. Together with Doctors for Choice, we are basing our efforts not on opinions or morality, but on years of medical and sociological research which shows that sex education, contraception, and accessible abortions make a society healthier. 

The irony was not lost on me when comments accusing me of being a baby-killing-mad-axe-murderer-who-doesn’t-understand-what-a-real-doctor-is started rolling in. Luckily for me, forewarned is forearmed, and the negativity failed to penetrate very deep. 

What did strike me was the contrast between the way people communicate their derision and their support. Abusive comments come in fast, prominent, and loud. Supportive comments are usually sent in private. At present, it’s clearly very easy to be openly anti-choice, but very difficult to be openly pro-choice. 

To those afraid to raise their voice and speak the truth, I say: whatever dogma, tradition, or a battalion of angry keyboard lieutenants might tell us, those who advocate for reproductive choice have nothing to be ashamed of. We are on the right side of history. 

Read more: Marston, C., & Cleland, J. (2003). Relationships between Contraception and Abortion: A Review of the Evidence. International Family Planning Perspectives, 29(1), 6. https://doi.org/10.2307/3180995

Stanger-Hall, K. F., & Hall, D. W. (2011). Abstinence-Only Education and Teen Pregnancy Rates: Why We Need Comprehensive Sex Education in the U.S. PLoS ONE, 6(10), e24658. https://doi.org/10.1371/journal.pone.0024658

Research to business plan: A metamorphosis

Author: Michelle Cortis

Michelle Cortis

In recent years, there has been a shift in the relationship between research and commercial industries. Commercial viability almost always comes into question for ongoing research. Commercialisation can be a boon. When a research project has demonstrated its potential to become a viable business, funding opportunities increase, meaning the research can be turned into a product or service that people can use.

In 2018, as part of a Masters in Knowledge-Based Entrepreneurship, I analysed the commercial potential of an ongoing University of Malta project. I conducted an in-depth market feasibility study on Prof. Ing Joseph Cilia’s Smart Micro Combined Heat and Power System, a device that can be fitted into homes and offices to deliver heat as a by-product of electricity, reducing energy costs. Many EU countries are setting up incentives to make these systems more feasible and attractive to consumers. 

For my dissertation, I developed a business plan for the research team. An engineer myself, and having earned a Masters by Research back in 2014, this was different to anything I had done before. My supervisors, Prof. Russell Smith and Dr Ing. Nicholas Sammut, helped me find the right balance between utilising my technical knowledge whilst also analysing the product’s commercial potential. Even my language changed through the process; I began to speak of ‘euros per day’ rather than ‘kilowatt hours’. I learnt to differentiate between technological features and what real benefits future users would gain.

Being presented with a physical product, initially one may assume that it is to be sold to customers, or protected through a patent and licensed to the private sector. However, my market analysis revealed new target audiences that had not been thought of before. Selling the device was not the only way to exploit the project’s commercial potential. What if we leased the product instead of selling it? Should we continue developing the product or is it already innovative enough? What if we developed a spin-out—would it be too expensive or is it worth the investment?  

By analysing a project through a commercial lens, all these questions arise, pointing out potential ways to make a good project great. But what makes a good business plan great is when all these questions are answered. 

The Project ‘A Smart Micro Combined Heat and Power System’ is financed by the Malta Council for Science & Technology, for and on behalf of the Foundation for Science and Technology through the FUSION: R&I Technology and Development Programme. 

Are you carrying out research at the University of Malta which you think may have commercial potential? If so, contact the Knowledge Transfer Office on knowledgetransfer@um.edu.mt

HERCULE project

The taxes of every citizen in the European Union (EU) contribute to the EU’s immense budget, and measures are needed to ensure these funds are used properly. Benjamin Charles Cassar talks to Prof. Ivan Sammut and Dr Jelena Agranovska, who are studying the effectiveness of such measures at a national level.

The EU’s Institutions operate throughout the continent on a massive scale, and in the 51 years since its conception, the scope of the EU has expanded to affect each and every one of our daily lives. The world would be very different without the Union. 

But this progress has not been without its hiccups. As Brexit’s deadline creeps closer, other countries, such as Hungary and Poland are experiencing political turbulence and rising Euroscepticism. Come the European Elections in May, these issues will bare their teeth. 

Despite this, the EU has had momentous victories in its pursuit of continental integration. Take, for example, the Common Market allowing for easy trade, the Schengen jurisdiction that simplifies travel, and the much-lauded mandate for free data roaming. The EU has also been moving towards harmonising its efforts to protect its financial interests.

Prof. Ivan Sammut and Dr Jelena Agranovska

In view of this, over the past few months, Prof. Ivan Sammut and Dr Jelena Agranovska (Faculty of Laws, University of Malta) have been leading the Hercule Project, a comparative study that looks into the implementation and enforcement of European Criminal Law. Together, they are investigating the development of legislation, focusing on the recent PIF (Protection of the Union’s Financial Interests) Directive. The aim is to increase people’s confidence in EU institutions and ensure that funds are managed transparently and appropriately. 

Apart from the legislative side, the study will also look into the bodies that work to protect the EU’s (and thus all its citizens’) financial interests—namely the European Public Prosecutor’s Office (EPPO), the European Anti-Fraud Office (OLAF), and Europol. 

To this end, Sammut and Agranovska selected 12 countries based on their size, geography, and legal system to gauge each state’s reception of European legislation. These countries include Germany and Malta, among a number of others. 

Each country report is being handled and written up by a local expert, with the team at the University of Malta offering guidelines and template questions. However, in practice, each team is given free reign on how to conduct their studies, as long as they stay true to purpose.

Recently, I had the opportunity to sit down with Sammut and Agranovska. They offered insight into its reasoning as well as the practical implications for citizens uninitiated in the intricacies of European law—myself included.

‘It affects everyone at the end of the day,’ Sammut notes. With blockchain and cryptocurrencies rapidly gaining interest, financial and IT crime protection are becoming more relevant to everyday life. ‘However, many times member states are only concerned when there is fraud with their own sources,’ Sammut continues. The PIF Directive will fit into existing national legal systems and balance out the field.

The project so far has revealed discrepancies in the uptake of legislation between Member States. Unsurprisingly, Sammut is quick to point out Germany as being at the forefront of implementation. Indeed, Angela Merkel is very proactive in most EU-level discussions. However, states such as Lithuania continue to lag behind, with standards seemingly lower than the rest of Europe. The election cycle can also complicate matters, as is the case with Poland. Initially eager to be part of EPPO, since their elections, this has become increasingly unlikely, with the Law and Justice Party consistently at odds with the European Union.

Diving deep into the implications for each state is impossible. However, the team noted these differences in implementation during a one-day workshop held in Valletta in October, when rapporteurs from each of the 12 participating countries came together to discuss their findings thus far. 

Dr Stefano Filletti, Malta’s rapporteur in the study, points out the issue with parallel administrative and criminal investigations. As things stand now, OLAF begins an administrative investigation, passes on the information to the Attorney General’s office, who in turn prompts the Maltese Police Force to begin its own investigation. This criminal investigation works independently of the previous administrative investigation, disregarding its findings and starting anew. The problem is efficiency. The two investigations should be synthesised, working in tandem, particularly because when investigating activities with a financial interest, speed is key. Dual investigations work against this goal. Filletti notes that while the PIF Directive should keep this goal at heart, it instead focuses on the definitions of offences, while remaining ‘completely silent’ on recovery.

Filletti notes the language barrier as one obstacle. For example, the Italian term sparizione dei soldi literally translates to ‘disappearance of funds’. However, this does not correlate to any Maltese law. So should we consider it as related to fraud? Or perhaps misappropriation?  

Prof. Jaan Ginter of Estonia echoes Filletti’s concerns on dual administrative and criminal investigations, raising the issue of non bis in idem, or double jeopardy. This relates to the concept that a person should not be tried twice for the same crime, which the PIF directive seemingly ignores, allowing for concurrent administrative and criminal proceedings. 

Harmonisation of penalties is also a concern for Ginter, as in some Member States (particularly Eastern members) a €1,000 penalty would be deemed steep, while others, such as Germany or Luxembourg, would see it as negligible.

In France, Dr Araceli Turmo notes that while politicians, judges and practitioners are approaching the legislation positively, a multitude of agencies need to show a more coordinated effort.

Agranovksa, serving a dual role as Latvia’s rapporteur, expects PIF Directive implementation to go smoothly, as many of its provisions are already in place. However, money laundering remains rife in the country, with the accusation this year that ABLV, Latvia’s third largest bank, has been perpetrating large-scale money laundering. Following the scandal, a law was urgently implemented outlawing shell companies. Further implementations will follow, and they are unlikely to encounter much opposition.

The general consensus remains that most national legal systems are not adequately prepared to take on European Law. However, this is partly why this study is taking place—to give states the tools they need to equip themselves. 

Sammut, Agranovska and their European counterparts have barely scratched the surface, and the implications of their work will certainly go far in understanding the limitations of the EU’s Member States. While the EU is faced with the immeasurable task of legislating for an incredibly diverse membership, it cannot continue going from strength to strength without considering this reality. Member states are not on a level playing field, and everyone needs to work together to adapt to this reality. 

Note: In June 2019, Sammut and Agranovska will be discussing the implications and scope of the study at a conference entitled 

EU & national criminal law in Fraud, Corruption, Blockchains: friends or foes? For more information, email Elisa Attard on elisa.attard@um.edu.mt.

Politics with a small ‘p’

Dù Theatre are back on stage after an absence of four years. Founder Simone Spiteri speaks to  THINK about her newly penned play Repubblika Immakulata co-produced by Spazju Kreattiv, the influences that motivated her to write it, and the importance of using daily language on stage. Words by Franica Pulis. 
Simone Spiteri

Repubblika Immakulata revolves around a Maltese family trying to cope, or not, with being involved in a general election, wedding, and local feast all on the same day. 

Premju Francis Ebejer winner Simone Spiteri (visiting lecturer, School of Performing Arts) wrote, and is directing, the satirical comedy as an exploration into Maltese identity and the climate of current affairs. 

‘So is it about political parties?’ is usually the first question most people blurt out when I’m only a quarter into explaining what Repubblika Immakulata is about,’ Spiteri says. But there is more. ‘The play tries to examine our relationship, locally, to straightforward politics drenched in election fever. But that is only part of the whole. The undeniable can’t be ignored. To say we are a country that is not affected, polarised, brainwashed even, by partisan politics would be a straight out lie. However, isn’t everything else that governs the rest of our lives another type of politics too? Don’t we all form part of smaller communities, and even smaller, family (or similar) units?’ she adds.

In the early days, Spiteri’s focus was always the people rather than the issues at hand. She was also very interested in exploring language. 

‘It was a time when most plays in Maltese didn’t tap into the mundanity of how we speak, how we sound, how we behave around each other. I was particularly interested in dissecting naturalistic dialogue. Code-switching from Maltese to English was not something you’d see characters do in most local plays,’ Spiteri points out.

‘I wanted to explore how the understated, rather than the epic and dramatic, worked in our mother tongue on stage and how audiences reacted to that. It was, relatively, a most welcomed effort. Not without the odd purist decrying the meshing of two languages in such a vernacular manner.’ 

   

Then, unexpectedly, came five years of writing commissioned plays for young people. It was not something Spiteri thought she could or wanted to do, but it was a challenge that ushered in a new way of thinking about writing. She describes it as a process that demands a thick skin. Young audiences were the toughest to please, she notes. The task demanded her to be exact, precise, and concise.

‘During these years, the niggling thought of going back to writing for an adult audience started bothering me. I didn’t feel the pull to write for pleasure. It felt more like the need to write to purge,’ Spiteri says.

‘There was plenty to write about. Perhaps that was the problem. All I had to do was read the daily papers or scroll through the latest bully-xenophobic-troll infested comment board online.’

‘Or eavesdrop everywhere on conversations between usually sensible individuals parroting away ‘facts’ straight out of a politician (of choice)’s mouth. Or take a stroll anywhere and witness every last speck of green on this tiny rock being gobbled up. Or observe everyone treat one other with some level of impatience, inconsideration, inhumanity. All I had to do was sit somehow and watch this fast-paced, technologically disconnected world pass by… and try to make sense of it.’

Spiteri reports this time in her life as one fraught with frustration, anger, and cynicism. The raw material was there, but moulding it into a play was proving a challenge. ‘I tried a few times, hated the attempt, and threw it away,’ she admits. ‘Then, last summer, the central character of Anon (portrayed by Andrè Agius) somehow popped into my mind and immediately all the disconnected loose ends clicked together.’ 

Anon (portrayed by Andrè Agius)

‘Here was my pivot to this rapid, sometimes nausea-inducing, merry-go-round. This character, who I didn’t want to define as anything but a voice, who speaks in the play, but you’re not sure is ever heard. Who speaks with authority one minute, but doubts that very same veracity a moment later. Who can be anyone… and no one at the same time. Who, by being there, is a blank canvas for us, upon which we project all those layers of beliefs, self-perceptions, subjective experiences of failure and success as a country, all the divergences of our multifaceted identity,’ Spiteri adds.

That’s how Repubblika Immakulata came to be. But that is not where the writing ends. Currently there is a new writing phase during which the actors imbue the script with their own interpretations during rehearsals. Then, there is the final act of writing: the process of each audience member looking into the metaphoric mirror the theatre stage should always be.  

Note: Repubblika Immakulata will be performed at Spazju Kreattiv, Valletta in March and April. For more information and tickets visit: www.kreattivita.org/en/event/repubblika-immakulata/

#GetLearnD

Students tutoring students

According to MATSEC, two in every three 18-year-old students don’t make it from sixth form to university. Gail Sant speaks to the team behind LearnD to find out more about their take on student-centred education.

You love films, videos, and photos. You relax while watching Netflix, and learn new skills on platforms like Skillshare and YouTube. Me? I adore the written word. Books, magazines, blogs are all I need to live a happy life. People are unique. And we all learn things in a unique way. 

Different people require different teaching methods to learn. But most classroom set-ups involve one teacher, one lesson, and thirty-odd students. The lesson is interpreted in thirty different ways; a few absorb more than others, leaving some in need of extra help to ace their maths test. And how do they do that? With private lessons. 

In Malta, private lessons are the go-to solution for students struggling with a subject. However, these sessions tend to be a carbon copy of school classes: one tutor, one lesson, multiple students. This problem was the seed that gave rise to the education-focused startup LearnD.

The philosophy  

LearnD is a tutoring app invented by Luke Collins, Jake Xuereb, and Dr Jean-Paul Ebejer (Centre for Molecular Medicine and Biobanking, University of Malta). The concept behind it is simple, Ebejer says; ‘it’s a bridge between students who can act as mentors and students who need the help.’ 

LearnD does away with the one-size-fits-all standard of teaching and offers students tailor-made tutoring. Individuals are treated as such, their problems tackled through dedicated sessions. As a student, you don’t need to sit through a whole syll

From left to right; Jake Xuereb, Dr Jean Paul Ebejer and Luke Collins. Photo by James Moffett

abus of private lessons. The idea is to identify your weak points and hone in on them in select sessions. This is both time and money-efficient. 

Xuereb believes ‘private lessons can make students lazy.’ They don’t need to evaluate their problems, or focus on where their issues lie. Not when they know they’ll just cover all the topics at various points during their weekly appointment with their second teacher on Tuesday night. LearnD focuses on dividing attention unequally. If you get an easy A in physical chemistry but struggle to pass organic chemistry, it only makes sense to give the latter some extra TLC. To get to this point, students need to take a step back from their desks and separate their strengths from their weaknesses. 

This is also a big plus for tutors who don’t want to (or can’t) commit to teaching a whole syllabus. They can simply prepare a lesson for the requested topic and leave it at that, earning some extra money to accompany their stipend while gaining teaching experience.

But LearnD isn’t just about academia. Some lecturers lose touch with ‘the student life’, distancing their relationship with students. Conversely, student-tutors know the struggles a peer would be going through and can provide support. ‘No one would have a better understanding of what a sixth former needs to do to get into medicine than a medicine student,’ says Xuereb. ‘Through LearnD you can find people who have been through the exact same thing and who can offer their best advice on anything from time management to de-stressing, and everything else.’

Making it happen

The original concept was more related to finding a way for academically inclined 6th form students to contribute productively to society,’ says Xuereb. When he spoke to Collins, a fellow University of Malta student and Xuereb’s former maths tutor, the idea went from ‘an online local network’ to ‘app’. At the time, there were no local tutoring apps.

Despite both being passionate about the idea, they soon realised that they needed someone with business experience, and that’s where Ebejer came in: the LearnD team was born!

The process that made this idea into reality was not a simple one. Xuereb and Collins spent over six months working on the app, learning about the tech behind app-making and coming up with a business plan.

They got their break when they won the Take-Off Seed Fund Award in 2018 and got the necessary funds to make the app a reality. They quickly got the ball rolling, hiring designers, app developers, and marketing agents. The team grew; the app was built. Then, during the KSU Freshers’ Week in 2018, the app was partially launched, inviting potential tutors to apply. The app is now fully launched and available for students.

Troubles

The app comes with features such as the ‘Location Filter’ that are there to make your life easier.

As with all big projects, the team ran into a few setbacks along the way. One prominent techy mishap didn’t allow them to launch the app on the Apple Store, making it difficult to keep up with the launch date. 

Since the app is used by underage students, there were also a lot of safety features which needed inclusion. Tutors upload their police conducts and ID cards. Also, to make sure LearnD’s service is reliable, the team not only analyses tutors’ qualifications, but they also try and test each applicant out themselves. And for accounts which belong to students under the age of 16, parents need to authorise any communication which goes on through the app.

The team persisted through the struggles they encountered and continue to work hard to solve any problems which crop up. Despite difficulties with time management, Collins and Xuereb, both undergraduate students, expressed how this app allowed them to dive into the working world. They gained entrepreneurial maturity, understanding the importance of a reliable team which shares the same ideas and work ethic, as well as dividing funds for the project’s overall benefit.

A LearnD future

The LearnD story doesn’t stop here. ‘We want to renovate the education space,’ says Ebejer, adding  that they wish to take the next step and make it internationally available. Malta’s size makes it the perfect test bed, but they think that the app shouldn’t be limited to its home.

According to MATSEC, in 2017 only 27% of 18-year-old students acquired the necessary qualifications to get into university. Collins expressed that students ‘shouldn’t get lost’ because of a bad exam result or because of a mismatched student-teacher scenario. Students deserve to be treated as individuals, and LearnD can offer them that. 

Written in blood

Maltese researchers are leading the way in developing new diagnostic tools for cancer. Dawn Gillies finds out more from Prof. Godfrey Grech and Dr Shawn Baldacchino.

Breast cancer survival rates have been improving steadily in recent years. In Malta, 86.9% of patients currently survive, up 7% over the last decade. Thanks to new targeted therapies, the outlook is increasingly bright. But precision therapies need precision testing.  

Breast cancer diagnosis has reached new heights and with current tests using tissue biopsies, pathologists can classify patients for specific treatment. Precision medicine goes a step further. It provides more information, predicting the aggressiveness of the cancer and measuring the number of cells from the tumour that spread into the bloodstream. 

Dr Shawn Baldacchino

This does not mean that all requirements in precision therapy have been met. 

At the time of writing, there is no simple method to test patients’ ongoing benefit from treatment or to measure different tumour areas from one sample. For this to be possible, we need super-sensitive tests. This is where Prof. Godfrey Grech and Dr Shawn Baldacchino at the University of Malta come in.

Detecting the undetectable  

During his PhD, Baldacchino studied a new class of breast cancer representing most cases of the triple negative type, which affects 12% of breast cancer patients in Malta. 

In triple negative breast cancers, tests for estrogen receptors, progesterone receptors, and excess HER2 protein all result in negatives and are associated with aggressive tumours.  

To detect this new class of breast cancer, Grech’s team have created a new test that uses molecular substances we naturally produce in our body—biomarkers. By pinpointing the right combination of certain biomarkers, they can test for this new class within the triple negative breast cancer cases.

They initially used the test to look at biopsies from past patients. These exercises showed that they could accurately detect the cases—even in samples that were over a decade old! In fact, the test was so successful that the team is now working with biological testing industry giant Luminex to use it in hospitals worldwide. With a patent filed, research labs will get their hands on it later this year with the hope that by 2021 it will be used to directly help patients in hospitals. 

However, there is more work ahead. Encouraged by the results so far, the team wants to take the test and other current biomarker tests a step further. They want to use a simple blood sample which is less invasive, allowing patients to be monitored during therapy.

Pushing boundaries

With the method Grech and his team have optimised, obtaining information on new classes of patients that predict therapy use, detecting different tumour areas in one sample, and the use of blood to monitor the benefits of therapy have become a

Prof. Godfrey Grech, Dr Shawn Baldacchino and the team
Photo by James Moffett

possible reality. With technologies from Luminex and Thermo Fisher, they can now read over 40 biomarkers in one test simultaneously. But with blood they need a new angle. And that is happening through another test using particles that originate from cells called exosomes.

Exosomes are tiny messenger bubbles which cells release into the blood . ‘We believe that when there is a tumour in the patient, there will be a signature in these exosomes circulating in the blood,’ says Baldacchino. 

Finding these exosomes could mean detecting cancer at an earlier stage than is currently possible. The team believes they would be able to detect the exosomes that point to cancer long before a tumour shows up in scans and other regular tests—and so, they would be able to nip the cancer in the bud. But to do this, they need to be able to decode the messages the exosomes are carrying.

Positives for patients

It’s not only in the realm of breast cancer diagnosis and classification that the team can help patients—they might also be able to improve treatment. ‘Most targeted therapies currently try to inhibit specific receptors and proteins to stop the uncontrolled growth of cancer cells,’ Grech says. But through their research, the team has found that targeting the low activity of specific complexes of proteins in tumour cells is key. Their research models show that increasing the activity of these protein complexes is possible using specific drugs.  

This is true for triple negative breast cancer, where the amount of PP2A protein is extremely low. The PP2A protein enables the body to fight the cancer, so increasing its activity would create a chain reaction in the body which could limit the growth and spread of that category of cancer cells.

This approach to treatment has applications beyond triple negative breast cancer. Grech is hopeful that PP2A production could be amped up for different types of cancer too, and lead to positive results.

Managing the unmanageable

When organising a project like this, it’s expected that things won’t go to plan. One of the biggest challenges for Grech’s team has been establishing collaborations with other groups across the globe. They need these connections to provide the samples required to test their systems. With other groups working on similar projects, time is a limited resource. Thankfully, the team found collaborators in Leeds (UK), and Barcelona (Spain), allowing the group access to the samples they need. 

What is certain is that support for this work has come in many shapes and forms. The project received funding both from public donations and the Malta Council for Science and Technology. Baldacchino also found an ally in the charity foundation Alive with the help of the Research Trust of the University of Malta (RIDT). He is the first recipient of funding from them, and their first graduate.

Predicting the future

Thanks to projects like these, cancer research has a bright future in Malta. The team has their product launch to look forward to later this year, which will see a drastic reduction to the time and effort it takes researchers and doctors to determine the type of breast tumour.

But a lot of challenges lie ahead. The biggest challenge will come in the move to early stage cancers. These cancers have low levels of substances to detect, which means that any test they develop will have to be extremely sensitive in order to be effective. Successfully identifying these cancers would signal a massive breakthrough for the global medical community—and, more importantly, for patients. Early detection through basic blood tests would open the door to early stage treatment and a higher rate of survival. Nothing could matter more. 

Project ‘Accurate Cancer Screening Tests‘ financed by the Malta Council for Science & Technology through FUSION: The R&I Technology Development Programme 2016.

Taking solar to sea

In a world first, a small team of engineers at the University of Malta is attempting to prove that harnessing solar power in the open sea is theoretically possible and cost-effective. Laura Bonnici speaks to Prof. Luciano Mulѐ Stagno to learn more about the ground-breaking Solaqua 2.1 project.

Renewable energy is in the spotlight. In Malta—an island that is said to enjoy an average of 300 days of sunshine per year—solar power has become mainstream, enabling the country to reach its goal of using 10% renewable energy by 2020. 

But any advantage Malta has in terms of abundant sunshine, it loses through its lack of another vital resource: space. Measuring just 316 km², Malta’s limited surface area means that, beyond the existing photovoltaic (PV) panels installed on rooftops or disused quarries, any land left for larger PV installations is rare and expensive. 

Prof. Luciano Mulѐ Stagno

Prof. Luciano Mulѐ Stagno at the University of Malta believes the answer to this problem lies not on land, but at sea. Malta being surrounded by water, he has proposed that installing solar panels in open water, in offshore floating PV farms, could be as cost-effective and reliable as those on land—an idea that has never progressed beyond the theoretical stage anywhere in the world. 

‘There are many PV projects happening on fresh water everywhere, from China and the UK to France and USA. But none of them are working on open sea,’ explains Mulѐ Stagno. ‘Their PV farms are installed in more sheltered, land-locked waters such as irrigation ponds or lakes, believing that PV farms cannot survive sea conditions. The Solaqua project aims to prove that they can survive, and do so at a comparable cost to land-based PV farms.’ 

When funding was secured from MCST in 2012, the previous Solaqua 1.0 project set about achieving these ambitious aims. Testing various prototypes out at sea, it confirmed that large, floating platforms were viable, cheap to construct, and could produce more power than similar systems on land.

The sea proved beneficial for many reasons. ‘The offshore panels produced around 3% more energy than similar land-based modules simply by being at sea, possibly due to the cooler temperatures at sea and a less dusty environment.’

The success of the first project inspired a second. With this one, the modular raft was designed and tested. ‘Solaqua 2.0 was financed by Takeoff [The University of Malta’s business incubator] in July 2017, with a preliminary design for the platform almost completed. Now discussions are underway about possible patents for the design,’ Mulѐ Stagno elaborates. ‘The ultimate aim is to launch a large farm in Maltese territorial water which, if it meets

Solaqua prototype 4 – testing concept of low cost structure

the cost and power output targets, will be followed by other systems worldwide.’

The Professor and his team (marine structural engineer Dr Federica Strati, systems engineer Ing. Ryan Bugeja, and engineer Martin Grech) are now starting the next phase of the Solaqua project. Before the team builds and launches a full-scale system, they have to conduct a series of rigorous wave tank tests. Using a scale model while mimicking the worst possible sea conditions that the system may encounter, the team will be able to refine the design and optimise power output by testing the effect of water motion, cooling, or even different types of panels. 

‘Through Solaqua 2.1, we hope to reassure investors that the system is viable. Once completed, we will be ready to launch a full-scale system that could be used not only by islands such as Malta, but also in coastal cities around the world which have insufficient land available for PV systems.’  

Investors are being invited to join this project to push for global commercialisation. To reach this stage, several local entities supported the project. The Regulator for Energy and Water Services, with the help of the RIDT (the University of Malta’s Research Trust), invested €100,000 to cover the cost of constructing the scale model, as well as testing, equipment, transport, and engineers. And now that the project is commanding international interest, potential investors are being sought for the half a million euros needed to achieve a full-scale floating solar farm in Maltese waters.

‘This is a homegrown project, in which Malta could be an example to the world,’ explains Mulѐ Stagno. ‘We have already placed Malta at the cutting edge of this research area by being the first to test small systems in the open sea. Now we need to find an investor willing to take the plunge and help us create the world’s first full-scale floating solar farm. With Solaqua, Malta could be at the forefront of a ground-breaking new global industry—one which has the potential to change the way solar power is collected and used the world over.’ 

Architecture: A dying art?

Making smart choices for our current urban fabric through architecture requires a massive understanding of all the moving parts of the industry. But is it time to go back to basics? Cassi Camilleri speaks to Prof. Antonio Mollicone and the talented people at AP Valletta to come up with an answer.

The changes in the Maltese landscape over recent years has been drastic. All over social media, petitions keep being shared to prevent one original building or another from being torn down and replaced with contemporary apartments. This has ‘resulted in discomfort for many,’ says Prof. Antonio Mollicone, an architect lecturing within the Faculty of Built Environment (University of Malta). 

Prof. Antonio Mollicone

The discomfort is multifaceted. On one level, it has to do with the physical climate within buildings. Over the last few decades, Malta has seen a shift in the property types people buy, and these properties seem to be leaving people hot or cold in their own homes.

Through his research, which used an old Maltese farmhouse as his case study, Mollicone found that ‘a property’s orientation, double skin (having two layers of brick walls), ceiling height and window measurements all have a role to play.’ Mollicone points out that ‘orientation is most important.’ In an ideal world, based on Malta’s position on the globe, ‘houses should be north-south facing and rotated clockwise to east by eight degrees to get the best of the sun in winter and the least of it in summer.’ Higher ceilings can create a four-degree difference in the temperature inside a room. As for the floor to ceiling windows you see in all the glossy magazines, Mollicone finds them problematic, noting the costs involved in terms of energy efficiency when replacing stone with glass. ‘Certain basic techniques in design are being lost in the fast-paced world of today,’ Mollicone asserts. 

Konrad Buhagiar (AP Valletta)

On this note, founding partner of AP Valletta, Konrad Buhagiar, says that with the ‘era of radical pragmatism’ we are currently living in, ‘the commercial aspect of a project is paramount,’ adding, ‘It will always be so. It is the nature of the industry.’ But with this being said, effort needs to be put into giving buildings and new projects a depth that ‘connects [them] to [their] context.’  

Even with the best of intentions, challenges still arise. Mollicone laments the flashy features he sees added to a building’s façade before a thought is given to function. ‘It’s make-up for buildings. Nothing more. I call it lipstick architecture.’

Luca Caruso, an environmental architect at AP, also speaks frankly, noting that the ‘construction sector is the least innovative worldwide.’ However, by putting an emphasis on quality and criticism, this can change. ‘Criticism is important in order to raise awareness about the possible consequences of Malta’s ‘uncontrolled’ growth. […] Debate can lead to new, innovative ways to inspire decision-makers while respecting local characteristics.’ 

The reality, as Caruso states, is that ‘Malta has undergone massive changes over the last 30 years, and this is a process that requires some more years to mature.’ Buhagiar announces himself a cynic, saying that ‘to produce something excellent, you need an enormous amount of thought and discipline, rigour, and dare I say, sacrifice, all words that do not describe the current culture in any way.’ But Mollicone has hope that common sense will prevail. ‘All we need is to take more time to think about things. Create mindfully. That’s all.’