Kidney Stakes

A small team of scientists at the University of Malta is trying to determine what causes children to be born with serious kidney defects. Laura Bonnici speaks to Prof. Alex Felice, Dr Valerie Said Conti, Esther Zammit, and Alan Curry to find out more about this ground-breaking programme.

‘I’d sell a kidney for that!’ Most of us have been guilty of using this expression when faced with something desirable. But do we fully appreciate the real value of what we are offering before the words escape our lips?

Kidneys are our body’s official waste disposal system, filtering out toxic build-up from our blood, which can poison us if left unchecked. With kidney failure posing such a threat, renal research has become an ongoing global goal.

A team of scientists from the University of Malta is currently honing in on what may cause children to be born with ‘CAKUT’, or Congenital Anomalies of the Kidney and Urinary Tract.

With between three and six cases recorded per 1000 live births worldwide, CAKUT is the most common cause of end-stage kidney disease in children. Since early identification of these anomalies may reduce kidney damage later in life, the LifeCycle Malta Foundation has raised funds for a renal research programme which targets CAKUT and its causes.

‘We know that a number of children are born with a kidney defect, but in many cases, we are not sure why,’ explains the programme’s principal investigator, Dr Valerie Said Conti . ‘There are many factors that can affect the development of the kidney, both genetic and environmental. We are trying to understand those influences so that we can carry out preventative strategies, diagnose issues earlier, and target personal therapeutic interventions.’

A number of children are born with a kidney defect, but in many cases, we are not sure why.

For this team of renal researchers, the first three years of initial research has been the first step in a far longer journey. ‘We hope to contribute our data to the international literature pool,’ continues Prof. Alex Felice, consultant and supervisor on the programme. ‘We will need a massive amount of data to create a robust theory with which to progress. We hope that our findings regarding CAKUT will be useful when we come to the stage of creating new interventions.’

It’s an end-game that has kept the small team focused as they approach the programme’s expected completion date this year. Having had to start literally from scratch, they collected biological samples from patients with a range of kidney diseases, including CAKUT, nephrotic syndrome, and Bartter syndrome. This allowed them to build the renal disease collection at the Malta BioBank, a vital storehouse for scientists.

‘For research projects like this, you see what material is available and you work with it,’ explains Said Conti . ‘A big part of it so far has been sourcing the samples from families attending the clinic with their formal consent for the material to be used in this project. We are hugely grateful to those who accepted to take part in the research. Without them, it would have been impossible.’

This project has set the groundwork for renal research in Malta to continue. ‘Without funding, projects such as this one simply could not exist,’ Said Conti remarks of the €100,000 donation LifeCycle Malta Foundation made to RIDT. ‘It enabled us to employ a full-ti me Research Support Officer, involve other laboratories, attend international meetings to share insights, perform ultrasound tests, and invest in ‘Next Generation DNA Sequencing’, genetic technology that maps out genes, revolutionising our world.’ But there is much more to come.

The Founder of the LifeCycle Malta Foundation, Personal Fitness Consultant Alan Curry, agrees. ‘Renal failure is an ever-increasing problem with figures going up every year, and LifeCycle is the only NGO that is actively supporting renal patients and their families in Malta. Our annual LifeCycle Challenge, which this year is routed from Dubai to Oman, aims to raise €150,000. It’s a huge responsibility, but we are sure that, by funding research programmes such as this, we will significantly improve the lives of kidney patients.’

  Author: Laura Bonnici

A Good Cause for Research

Mario Cachia

Why should public, private, and non-profit entities invest in research? Several reasons exist.

Firstly, research is key for our future. Research helps drive new knowledge that will improve the world. Society depends on research, across a wide range of disciplines, to strengthen our quality of life and sustain economic stability. By raising funds for University research the RIDT is surely not trying to reinvent the wheel. On the contrary, throughout Europe, the US and Asia public universities are enhancing their Government funding through various initiatives to sustain important research. Universities all across the globe appeal to public entities, private individuals and NGOs to fund research and invest in our society’s future.

Locally, we have just started scraping the surface of fundraising for research. Recently, the RIDT received a number of important donations which shall serve to continue fostering local research. In the first of its kind, we received €55,000 from local NGO ‘Action for Breast Cancer Foundation’ (ABCF), raised through the ALIVE Cycling Challenge. They are being used to launch a Ph.D. studentship in breast cancer research. The Lifecycle Foundation has also donated €70,000 towards kidney disease research. These NGOs have followed a stream of public and private entities, as well as students, who have been donating money for research for the last three years.

Secondly, don’t you want to be part of something bigger? You probably cannot find the cure for cancer yourself, but everyone can contribute to make that a possibility. As the University’s Research Trust, we do not only want to attract big corporate companies or NGOs to donate money, but we also want you — the students, the alumni, the professionals, the workers, the parents, to realise that donating for research is a noble cause. A recent Christmas campaign at the University of Malta that was spearheaded by KSU, the UoM staff and the Chaplaincy managed to raise €12,000 from students, staff, and academics on campus. A third of these funds were donated to the RIDT, which were devolved to the Department of Anatomy. They will be invested in specialised research projects focusing on specific strands of cancer, such as leukaemias, sarcomas, brain tumours, breast and colon cancer.

Research affects our day-to-day lives. Though research discoveries take time and need constant investment to benefit our society, we can come together as a Maltese community by investing in research for good causes. Ultimately, let us imagine a world where we have cured all major diseases, where we can move objects with our thoughts, and unravel the mysteries of the universe.Imagine, and let’s make it happen!

 

RIDT is the University’s Research Trust aimed towards fostering awareness and fundraising for high-calibre local research. We aim to achieve this by raising funds for various research projects undertaken at the University of Malta. Please visit www.ridt.eu to donate and our Facebook page on www.facebook.com/RIDTMalta for more information about our latest events and initiatives.